Bloodborne Viruses Timeline

Below is a timeline outlining milestones in bleeding disorders treatments and HIV/hepatitis C virus in Australia and around the world. HFA has compiled this timeline from the sources listed in the references to provide information for the Australian bleeding disorders community. Please click the image to expand.

References:

1. Schramm W. The history of haemophilia – a short review. Thrombosis Research Nov 2014;134(Suppl. 1):S4-S9.
2. Australia. Report of the Expert Advisory Group on Hepatitis C and Plasma in 1990. Canberra: Australian Department of Health and Ageing, 2003. [Barraclough Report].
3. Espanol MG, Mistretta JN, Tarantino MD, Roberts JC. The evolution of hemophilia therapeutics: an illustrated review. Research and Practice in Thrombosis and Haemostasis 2024;8:e102308. https://doi.org/10.1016/j.rpth.2023.102308
4. Craske J, Dilling N, Stern D. An outbreak of hepatitis associated with intravenous injection of factor-VIII concentrate. Lancet. 1975 Aug 2;2(7927):221-3.
5. Hruby MA, Schauf V. Transfusion-related short-incubation hepatitis in hemophilic patients. JAMA. 1978 Sep 22;240(13):1355-7.
6. Australia. Senate Community Affairs References Committee. Hepatitis C and the blood supply in Australia. Canberra: Senate Community Affairs References Committee Secretariat, 2004.
7. Cossart YB, Kirsch S, Ismay SL. Post-transfusion hepatitis in Australia: report of the Australian Red Cross Study. Lancet 1982 Jan 23;1(8265):208-13. doi: 10.1016/s0140-6736(82)90770-x.
8. Centers for Disease Control. Pneumocystis carinii pneumonia among persons with haemophilia A. Morbidity and Mortality Weekly Report 16 July 1982;31:365-367.
9. Garsia RJ, Gallagher KJ, Gatenby PA et al. Australian hemophiliac recipients of voluntary donor blood products longitudinally evaluated for AIDS. A clinical and laboratory study, 1983-1986. Australian and New Zealand Journal of Medicine 1987;17:371-378.
10. Garsia RJ, Ross J, Shipway P, Wylie B. Medically acquired HIV infection. Medical Journal of Australia 1 July 1996;165:36-38.
11. Evatt B. Infectious disease in the blood supply and the public health response. Semin Hematol. 2006 Apr;43(2 Suppl 3):S4-9. doi: 10.1053/j.seminhematol.2006.02.001.
12. Colombo M, Mannucci PM, Carnelli V, Savidge GF, Gazengel C, Schimpf K. Transmission of non-A, non-B hepatitis by heat-treated factor VIII concentrate. Lancet. 1985 Jul 6;2(8445):1-4.
13. Safer factor VIII and IX. [editorial] Lancet 1986 Aug 2;2(8501):255-6.
14. C R Hay, F E Preston, D R Triger, J C Underwood. Progressive liver disease in haemophilia: an understated problem? Lancet 1985 Jun 29;1(8444):1495-8. doi: 10.1016/s0140-6736(85)92264-0.
15. Australian Government. Report of the Expert Inquiry on Hepatitis C and Plasma in 1990, May 2003 (Barraclough Report), p 78. Referring to a September 1989 report in Transfusion Today.
16. Colvin BT, Rizza CR, Hill FGH, Kernoff PBA, Bateman CJT, Bolton-Maggs P. Effect of dry-heating of coagulation factor concentrates at 80 degrees C for 72 hours on transmission of non-A, non-B hepatitis. Study group of the UK haemophilia centre directors on surveillance of virus transmission by concentrates. Lancet. 1988;2:814–816.
17. Lusher JM. Hemophilia: from plasma to recombinant factors. In American Society of Hematology. 50 years in hematology: research that revolutionized patient care. Washington DC: ASH, 2008.
18. Australian Red Cross Lifeblood. Our history. https://www.lifeblood.com.au/about/our-history
19. Parliament of Australia. National Blood Authority Bill 2003. Australian Government, 2003.
20. Roberts A. Recombinant factor VIII and IX for haemophilia – success at last; discrimination to end. National Haemophilia Oct 2004;148:1-3.
21. Australian Haemophilia Centre Directors’ Organisation. 2020. Current health status of Australian patients with hepatitis C and bleeding disorders. Unpublished AHCDO Project Report.