Rebalancing therapies
A fact sheet on rebalancing therapies for people with haemophilia, their families and carers.
It explains how rebalancing therapies work, types of rebalancing therapies (tissue factor pathway inhibitors or TFPIs and small interfering RNAs or SiRNAs), who they are for and how they are given. It covers treatment safety (side-effects) and living well with treatment. Includes a diagram showing how rebalancing therapies work.
(October 2025)
Download fact sheet PDF 496 KB
Acknowledgments
This fact sheet has been funded by unrestricted education grants from CSL Behring and Sanofi. This funding is based on a mutual understanding that HFA will act independently for the benefit of the bleeding disorders community. HFA does not promote any particular pharmaceutical product. Where possible products are referred to by their class or generic name and any mention of any commercial brand is strictly for educational purposes.